斯里兰卡妇女的三季度特异性甲状腺激素参考数据
Kamani Dhanushka Liyanarachchi1, Dimuthu Tharanga Muthukuda2, Udari Apsara Liyanage3
1Endocrinology and Diabetes unit, National Hospital, Sri Lanka.
The Ceylon medical journal
|August 23, 2023
概括
斯里兰卡孕妇的甲状腺参考范围与高加索地区的值更符合,而不是区域的值. 这项研究为这一群体建立了三个月特定的甲状腺功能测试范围.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 公共卫生 公共卫生
背景情况:
- 甲状腺激素的区域差异很大,特别是在怀孕期间.
- 建立准确的甲状腺功能参考范围对于母亲和胎儿的健康至关重要.
研究的目的:
- 为了确定斯里兰卡孕妇的三季度特异性甲状腺功能测试参考值.
- 将这些值与区域和国际数据进行比较.
- 为了确定甲状腺过氧化酶 (TPO) 抗体阳性和缺乏症的患病率.
主要方法:
- 一项横截面研究排除了甲状腺疾病,甲状腺超声波异常或高风险因素的参与者.
- 在三个月内建立了一个"理想参考人群".
- 用化学发光测量甲状腺激素;使用中位数和百分位数得出参考范围.
主要成果:
- 最终的样本包括369名女性.
- 建立了三季度特异的TSH参考范围:0.014-2.77 mIU/L (第一个),0.31-3.2 mIU/L (第二个) 和0.34-3.4 mIU/L (第三个).
- 在TPO抗体水平和TSH之间发现了微弱的相关性;在尿液中和甲状腺功能之间没有观察到任何关联.
结论:
- 导出的TSH参考范围与高加索地区的值相比,更符合地区的值.
- 研究设计,参考人群选择和激素测量试验的方法差异可能解释了观察到的差异.
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