在预测最佳卵细胞产量之后的LH最大水平的值引发了GnRH激动剂的触发
William Hao-Yu Lee1, Kuan-Ting Lin1, Yun-Chiao Hsieh1
1Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
Frontiers in endocrinology
|August 23, 2023
概括
在受控卵巢刺激 (COS) 期间,最大的黄化激素 (LH) 水平可以预测最佳的卵细胞产量. 持续低的LH水平与低于最佳的反应有关,这表明最大的LH是一个比基底LH更好的预测指标.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症治疗方法 不孕症治疗方法
- 卵巢刺激协议 卵巢刺激协议
背景情况:
- 对性激素释放激素 (GnRH) 激动剂的低于最佳反应与BMI,口服避孕药的使用以及低性激素 (LH) 水平有关.
- 目前的策略可能会增加对双触发器的需求,以及在高反应者中增加卵巢过度刺激综合征 (OHSS) 风险.
研究的目的:
- 为了调查在受控卵巢刺激 (COS) 期间的最大LH水平是否预测了单独使用GnRH激动剂触发器的最佳卵细胞产量.
- 评估最大LH水平作为辅助生殖技术中卵细胞产量的预测因素的有效性.
主要方法:
- 仅使用GnRH激动剂触发的对抗剂或孕激素原始卵巢刺激 (PPOS) 协议的回顾性审查 (2012年5月至2022年12月).
- 研究对象根据COS期间的LH基底和最大水平分为三组:恒定的低LH,低基底与高最大LH,以及恒定的高LH.
- 主要结果:卵细胞产率. 二次结果:卵细胞成熟,受精,怀孕和活产率.
主要成果:
- 在整个COS (组1) 中持续低的LH水平独立预测了次优反应 (OR:6.99).
- 持续较低的LH水平 (1组) 和较高的BMI与卵细胞产率有负相关性.
- 基底LH水平较低但LH水平较高的患者的临床结果与恒定的高LH水平患者相似.
结论:
- 在COS期间的最大LH水平比单独的基底LH水平更可靠地预测最佳卵细胞产量.
- 提出了一种新的策略,包括最大的LH水平,而不仅仅是基底水平或触发日水平,用于评估超响应者中的LH储量.
- 这种方法旨在最大限度地减少低于最佳的卵细胞产量,并提高辅助生殖治疗的整体治疗结果.
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