闪光血糖监测系统产生的血糖指数与糖尿病血管并发症之间的相关性
1Department of Endocrine, The First Hospital of NanChang City, Nanchang, Jiangxi, 330008, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|August 23, 2023
概括
2型糖尿病的较低时间范围 (TIR) 与较高的血管并发症风险有关. 整合TIR和其他葡萄糖监测指标可以改善糖尿病管理和预测.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 眼科医生 眼科 眼科
背景情况:
- 2型糖尿病 (T2DM) 的管理依赖于血糖控制.
- 持续葡萄糖监测 (CGM) 提供了关于葡萄糖变化的见解.
- 射程时间 (TIR) 是一个关键指标,但它与血管并发症的关系需要进一步探索.
研究的目的:
- 调查TIR之间的关联,不包括来自闪光血糖监测系统 (FGMS) 的数据,以及糖尿病血管并发症的风险.
- 建立TIR和其他缺少FGMS的指数的临床使用的理论基础.
主要方法:
- 连续使用FGMS的T2DM患者被监测了一年.
- 记录了关键的血糖指数,包括TIR,时间低于范围 (TBR),时间高于范围 (TAR),血糖标准偏差 (SDBG),变化系数 (CV) 和平均血糖外流幅度 (MAGE).
- 考克斯比例危险回归分析了TIR水平与糖尿病血管并发症率之间的关联.
主要成果:
- TIR显示与HbA1C,CV,SDBG和平均外出 (MV) 有负相关性.
- 在患有微血管并发症的患者中观察到明显较低的TIR.
- <40%的TIR被确定为糖尿病病 (DN),神经病 (DPN) 和视网膜病 (DR) 的危险因素.
- 较高的TAR,CV,SDBG,MAGE和HbA1C与增加的并发症率有关.
结论:
- 在TIR,HbA1C和糖尿病血管并发症的患病率/风险之间存在负面关系.
- 为全面的血糖控制和并发症预测,建议整合其他CGM衍生指数,如CV和MV.
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