病毒感染的炎症酶激活:激活和调节的机制
Wen Shi1, Mengyun Jin1, Hao Chen1
1College of Animal Science and Technology, Guangxi University, Nanning, China.
Frontiers in microbiology
|August 23, 2023
概括
炎症酶是关键的先天性免疫传感器,对抗病毒防御至关重要. 这篇评论探讨了病毒如何激活或抑制炎症体,为新的抗病毒疗法提供了洞察力.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 分子生物学分子生物学
背景情况:
- 病毒性疾病对人类和动物健康构成重大全球威胁.
- 炎症酶,天生的免疫系统组件,对于宿主防御病毒感染至关重要.
- 病毒可以操纵炎症酶激活以实现自身复制.
研究的目的:
- 审查病毒感染中炎症体的生物特性.
- 讨论病毒对炎症酶激活和抑制的机制,重点关注NLRP1,NLRP3和AIM2.
- 探索病毒感染和炎症酶调节之间的相互作用,用于抗病毒疗法开发.
主要方法:
- 在病毒感染期间对炎症体功能的文献综述.
- 对炎症酶调节的病毒策略的分析.
- 对抗病毒免疫中NLRP1,NLRP3和AIM2炎症体的当前知识的综合.
主要成果:
- 炎症酶对检测病毒病原体和启动炎症反应至关重要.
- 不同的病毒使用不同的机制来激活或逃避炎症监测.
- 病毒复制和NLRP3炎症酶活性之间存在相互调节.
结论:
- 了解病毒感染期间的炎症动态对于宿主防御至关重要.
- 准炎症体通路为新型抗病毒药物发现提供了一个有前途的途径.
- 对炎细胞激活机制的进一步研究可以增强抗病毒策略.
相关概念视频
Immune Response Against Viral Pathogens
824
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
824
Inflammatory Response
2.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.1K
Inflammatory Response I: Vascular and Cellular
11.3K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.3K
Inflammation
53.8K
Overview
53.8K
Viral Structure
62.4K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
62.4K
Antimicrobial Proteins
1.0K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
1.0K


