在儿童中Streptococcus intermedius感染的临床特征:一个案例系列研究研究
Zhufei Xu1, Lichao Gao2, Dan Xu1
1Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Frontiers in microbiology
|August 23, 2023
概括
在儿童中,Streptococcus intermedius感染往往导致,特别是在腹部. 高通量测序可以帮助诊断,即使是负面培养,侵入性肺部感染.
科学领域:
- 儿童传染病 儿童传染病
- 细菌学 细菌学是一门学科.
- 临床微生物学 临床微生物学
背景情况:
- 介质链球菌 (Streptococcus intermedius) 是一种机会性病原体,与成人严重结局有关.
- 关于儿科中介性链球菌感染的临床数据有限.
研究的目的:
- 描述儿童中Streptococcus intermedius的临床特征,感染部位和抗生素敏感性.
- 突出诊断挑战和潜在的改进.
主要方法:
- 回顾40名患有中型链球菌感染的儿童的病例系列.
- 细菌培养和高通量测序用于诊断.
- 抗生素敏感性测试和临床表现的评估.
主要成果:
- 最常见的感染部位:腹腔,皮肤/软组织,内和肺部.
- 对塞夫特里亚克松,万科米辛和线索利德的高度敏感性;对红红和克林达米辛的显著耐药性.
- 肺部干扰包括腹和肺部溢出;高通量测序确定了负性培养病例.
结论:
- 在儿童中,Streptococcus intermedius感染带有/形成的高风险.
- 考虑小儿肺/多发性溢液中的Streptococcus intermedius,即使有负的培养物.
- 高通量测序的进步对于尽量减少误诊至关重要.
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