药剂师参与败血症反应和抗生素的时间:系统性审查
Payton E Atkins1, Melissa L Thompson Bastin1,2, Rebecca J Morgan3
1Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA.
Journal of the American College of Clinical Pharmacy : JACCP
|August 23, 2023
概括
药剂师参与败血症反应显著减少了败血症患者服用抗生素的时间. 这一系统性审查强调了药剂师在通过加快抗生素给药来改善败血症护理和患者治疗结果方面发挥的关键作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 败血症是一种严重的医疗紧急情况,在全球范围内死亡率很高.
- 及时服用抗生素对于改善败血症生存率至关重要.
- 活下来败血症运动的指导方针强调在识别后一小时内服用抗生素.
研究的目的:
- 评估药剂师参与败血症反应对抗生素给药时间的影响.
- 评估药剂师参与与败血症患者的重症监护结果之间的关联.
主要方法:
- 来自PubMed/MEDLINE,Embase,CINAHL和Web of Science的研究的系统审查.
- 包含了药剂师在败血症/败血症休克管理中的定义角色的研究.
- 主要结局:抗生素给药时间;次要结局:ICU/住院时间长度,住院死亡率.
主要成果:
- 分析了10项涉及1772名患者的研究.
- 七项研究表明,药剂师参与的抗生素治疗时间显著减少.
- 没有观察到ICU/住院时间或住院死亡率的持续减少.
结论:
- 药剂师参与败血症反应与更快的抗生素管理有关.
- 这种效果往往是通过多专业,以团队为基础的治疗败血症的方法来实现的.
- 加快抗生素的输送是将药剂师纳入败血症应对小组的关键好处.
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