在患有指底部骨关节炎的患者中,多部位非手关节干扰的频率,以及与功能和患者报告结果的关联
Anthony V Perruccio1,2,3,4, Elizabeth M Badley1,2,5, Daniel Antflek1
1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Canada.
Osteoarthritis and cartilage open
|August 23, 2023
概括
近80%的指骨关节炎患者在其他关节出现症状. 这种全身骨关节炎负担与手部功能和疼痛的恶化有关,影响了治疗和研究设计.
科学领域:
- 类风湿病学 类风湿病学
- 整形外科 整形外科 整形外科
- 流行病学 流行病学
背景情况:
- 骨关节炎 (OA) 的研究通常集中在单个指针关节上,忽视了其他受影响的部位.
- 大指底部OA很常见,但同时出现症状的非手关节关节的程度经常被低估.
研究的目的:
- 在患有指底部OA的患者中记录非手部关节部位症状的频率.
- 调查非手关节症状部位数量与指特异性功能和患者报告结果之间的关联.
主要方法:
- 一组145名患有指底部骨关节炎的患者填写了有关人口统计,健康和症状关节部位的问卷.
- 患者报告的结果包括疼痛强度,指症状和残疾 (TASD) 和上肢残疾 (快速DASH).
- 测量了握力和力,线性回归分析了症状关节部位数和结果之间的关联.
主要成果:
- 参与者的平均年龄为62岁,72%是女性.
- 平均每名患者报告有3.6个非手部关节部位有症状.
- 近80%的患者有两个或两个以上的非手部关节部位有症状.
- 症状较高的非手关节部位数与患者报告的结果较差和握力降低相关.
结论:
- 大多数大指底部OA患者在多个非手关节中表现出症状.
- 这种广泛的OA负担与较差的指特异性结果有关,突出了需要采用整体方法的需要.
- 这些发现对解释结果得分,设计临床试验和管理指基础OA患者有影响.
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