基于二元固体脂质矩阵的布洛芬载体固体脂质纳米颗粒的增强稳定性和皮肤透性:表面活性剂和脂质组成的影响
Thitirat Chantaburanan1, Veerawat Teeranachaideekul1, Anchalee Jintapattanakit1
1Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Sri-Ayutthaya Road, Rajathevee, Bangkok 10400, Thailand.
International journal of pharmaceutics: X
|August 23, 2023
概括
乳化剂的选择显著影响固体脂质纳米粒子 (SLN) 的特性和布洛芬释放. 不同的乳化剂和脂质组成改变了皮肤应用的SLN性能.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 皮肤病学 皮肤病学
背景情况:
- 固体脂质纳米颗粒 (SLN) 是多功能药物输送系统.
- 乳化剂的选择对SLN的物理化学特性和稳定性至关重要.
- 了解乳化剂效应是优化SLN配方用于皮肤输送的关键.
研究的目的:
- 为了比较不同乳化剂对SLN的影响.
- 评估SLNs的物理化学特性和体外皮肤性能.
- 为了研究用 cetyl palmitate (CP) 和 Softisan® 378 (S378) 脂质混合物配制的 SLNs.
主要方法:
- 使用CP,S378或CP:S378混合物制备SLN,使用Tego®Care 450 (TG450) 或poloxamer 188 (P188) 稳定.
- 物理化学性质 (颗粒大小,PDI,ZP,EE,%CI,多态) 在生产后和180天后进行评估.
- 进行了体外药物释放和皮肤透的研究.
主要成果:
- 使用P188稳定的SLN显示出比使用TG450.的更小的颗粒大小.
- 在180天后,SLN粒子大小仍低于250nm.
- 添加S378修改了易布洛芬释放和皮肤透,增强了表皮透和保留.
结论:
- 乳化剂的选择会影响SLN的特性和易布洛芬的输送.
- 含有S378的SLN配方显示出改善局部布洛芬输送的潜力.
- 储存条件和配方成分会随着时间的推移影响SLN的性能.
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