通过皮肤的宫迷走神经刺激可以改善人类的感官表现
Michael Jigo1, Jason B Carmel1,2, Qi Wang1,3
1Sharper Sense, Inc., New York, NY.
bioRxiv : the preprint server for biology
|August 23, 2023
概括
通过皮肤进行的迷走神经刺激 (tcVNS) 显著提高了人类的听觉和视觉感官性能. 这种非侵入性方法为治疗中央感官处理缺陷提供了一个有希望的方法.
科学领域:
- 神经科学是一个神经科学.
- 感官系统 感官系统
- 医疗干预 医疗干预
背景情况:
- 准确的感官感知依赖于受体功能和中央神经处理.
- 虽然感觉受体的恢复正在推进,但对受损的中央感觉处理的有效治疗方法有限.
- 之前的动物研究表明,侵入性迷走神经刺激 (VNS) 通过位置 - 北上腺素系统改善了中央感官处理.
研究的目的:
- 调查穿皮VNS (tcVNS) 是否可以提高人类的感官表现.
- 评估tcVNS对听觉和视觉处理的影响.
- 评估tcVNS对心率变化 (HRV) 的影响,以此衡量阴道接触.
主要方法:
- 三个模拟控制实验,每个实验涉及12个神经类型的成年人.
- 连续穿皮VNS应用于部 (tcVNS) 或耳部 (taVNS) 迷走神经分支.
- 对于听觉和视觉表现的心理物理任务,以及在被动观看期间的HRV测量.
主要成果:
- 与假药相比,tcVNS显著提高了37%的听觉表现 (p=0.00052) 和23%的视觉表现 (p=0.038).
- 基线表现较低的个体在tcVNS (p=0.0040) 中表现出更大的改善.
- 在被动观看期间,tcVNS增加了HRV,证实了神经的参与;taVNS没有显著影响.
结论:
- 透皮VNS,特别是tcVNS,是提高人类感官表现的有效方法.
- 这种非侵入性技术显示出对中央感官处理功能障碍的按需治疗的潜力.
- 研究结果支持tcVNS作为感官障碍的可行治疗策略.
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