The HuMet Repository:观察人类代谢在工作中的过程
Patrick Weinisch1, Johannes Raffler1,2, Werner Römisch-Margl1
1Institute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
bioRxiv : the preprint server for biology
|August 23, 2023
概括
胡梅特存储库提供了一个全面的,时间解析的代谢学数据集,用于健康的人类对生理挑战的代谢反应. 该资源有助于研究人员了解健康和疾病中的新陈代谢动态.
科学领域:
- 人类的新陈代谢.
- 代谢学 代谢学 代谢学
- 生理学上的挑战.
背景情况:
- 人类的新陈代谢动态地适应饮食,运动和压力等刺激.
- 对于健康个体来说,详细的,时间解析的代谢数据很少.
- 了解这些反应对于健康和疾病研究至关重要.
研究的目的:
- 建立 HuMet 存储库,这是一个基于网络的资源,用于探索动态代谢反应.
- 整合来自健康受试者在各种生理挑战下的多样化的代谢学数据.
- 为访问,分析和可视化时间解析的代谢数据提供一个工具.
主要方法:
- 收集了15名健康男性的新陈代谢数据,涉及6个标准化的生理挑战 (运动,禁食,营养负载,寒冷压力).
- 在最多56个时间点测量血液,尿液和呼吸样本中的代谢物.
- 整合了超过110万个数据点,涵盖2656种代谢物,并将其集成到一个交互式Web应用程序中.
主要成果:
- 开发了HuMet存储库,包含2656种代谢物的时间解析代谢组数据.
- 该存储库允许用户搜索,过,分析和可视化动态代谢资料.
- 展览展示了库存对生物见解和假设生成的实用性.
结论:
- 胡米特储存库作为健康的人类代谢反应的宝贵参考.
- 它使研究人员能够研究人类新陈代谢的动态.
- 该资源有助于更深入地了解健康和疾病中的代谢途径.
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