人类大脑皮层的个人内部组织:网络,全球地形和功能
Jingnan Du1, Lauren M DiNicola1, Peter A Angeli1
1Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
bioRxiv : the preprint server for biology
|August 23, 2023
概括
这项研究揭示了人类大脑皮层内嵌的网络组织,从主要的感官区域向外移动到复杂的关联网络. 这些发现突显了大规模大脑网络中重复的结构模式和功能专业化.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 系统神经科学 系统神经科学
背景情况:
- 人类大脑皮层表现出专门的区域,这些区域组织成功能网络.
- 了解这些大规模大脑网络的层次组织和功能性质对于破译认知过程至关重要.
研究的目的:
- 用密集功能性MRI (fMRI) 数据估计和描述人类大脑皮层的网络组织.
- 调查不同网络顺序的功能专业化,并在协会皮层中识别重复的组织动机.
主要方法:
- 应用了多会话层次贝叶斯模型 (MS-HBM) 来密集采样来自多个参与者的个人fMRI数据.
- 分析了网络结构,确定了超现实协会巨型集群 (SAAM),并使用独立任务数据探索了功能响应属性.
主要成果:
- 揭示了皮质网络的全球层次组织,从主要的感觉/运动到更高层次的关联网络.
- 确定了超现实协会巨型集群 (SAAMs),具有域专业化和控制区域的重复模式.
- 在第三级网络中表现出功能专业化,区分域-灵活控制区域和域-特定处理区域.
结论:
- 大脑皮层组织成逐渐嵌套的网络,从主要的感觉/运动区域向外扩展.
- 协会皮层中重复的组织动机表明了管理大规模网络专业化的基本原则.
- 研究结果提供了关于皮质组织和功能专业化在发育过程中出现的见解.
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