血液动力学表明,在左心室辅助装置植入后,中风患者和没有中风患者之间的结果不同
medRxiv : the preprint server for health sciences
|August 23, 2023
概括
用左心室辅助器 (LVAD) 治疗心力衰竭患者的数字双胞胎的血液动力学分析可以预测中风风险. 从植入前到植入后的定量流动模式和变化揭示了对中风病因学的洞察力.
科学领域:
- 心血管工程 心血管工程
- 计算流体动力学的流体动力学.
- 医疗成像医学成像
背景情况:
- 脑卒中是左心室辅助装置 (LVAD) 患者的主要并发症.
- 血液动力学显著影响LVAD后中风风险和原因.
- 在LVAD患者中进行定量血液动力学评估具有挑战性.
研究的目的:
- 在使用数字双胞胎的LVAD患者中分析in silico血液动力学.
- 为了将血液动力学变量与中风结果相关联.
- 探索植入前血液动力学作为植入后中风的预测因素.
主要方法:
- 为12名LVAD患者创建数字双胞胎 (6次中风,6次没有中风).
- 使用CT扫描重建植入后双胞胎和植入前双胞胎,估计基线流量.
- 使用螺旋流,旋生成和壁剪压力描述器来描述血液动力学.
主要成果:
- 患有中风后果的患者显示出更高的平均螺旋流量,旋生成和壁剪压力.
- 与植入前流量相比,在中风病例中,LVAD驱动的流量具有更高的螺旋性和更低的旋转性/墙面剪切.
- 从植入前到植入后的血液动力学变化与中风发生有关.
结论:
- 在LVAD患者的定量血液动力学分析可以识别中风风险.
- 数字双胞胎为了解中风病因和优化LVAD治疗提供了一个平台.
- 这种方法对LVAD治疗计划,手术优化和疗效评估有影响.
相关概念视频
Cardiac Output II: Effect of Stroke Volume on Cardiac Output
1.0K
Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
1.0K
Cardiomyopathy V: Interprofessional Care
16
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
16
Regulation of Stroke Volume
3.3K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
3.3K


