将人口级数据源集成到个人级临床预测模型中,以测试登革热病毒的阳性
R J Williams1, Ben J Brintz1,2, Gabriel Ribeiro Dos Santos3
1Division of Infectious Diseases, Department of Internal Medicine, University of Utah, Salt Lake City, USA.
medRxiv : the preprint server for health sciences
|August 23, 2023
概括
从其他发烧性疾病区分登革热病毒 (DENV) 感染至关重要. 将人口层面的数据与临床因素相结合,显著改善了在泰国识别DENV的预测模型.
科学领域:
- 流行病学 流行病学
- 传染病建模传染病建模
- 医疗保健中的机器学习
背景情况:
- 区分登革热病毒 (DENV) 感染与其他导致急性发烧疾病的病因对于适当的临床管理和抗生素管理至关重要.
- 传统的临床预测模型通常仅依赖个体患者的数据,这可能会限制它们对传染病的准确性.
- 包括气候和流行病学因素在内的人口级数据可能会增强用于识别DENV的模型的预测能力.
结论:
- 将患者外部数据 (如气候和流行病学因素) 与临床信息相结合,为预测登革热病毒感染提供了更强大的方法.
- 开发的模型显示了在资源有限的环境中提高DENV诊断准确性的前景,有助于更好地对患者进行分拣和资源分配.
- 进一步验证和实施这些模型可能会导致更有针对性的实验室测试,并减少对发烧性疾病不必要的抗生素使用.
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