显示联结体的E. coli细胞和迷你细胞通过IV型分泌系统可编程输送有毒有效载荷
Yang Grace Li1, Kouhei Kishida1,2, Natsumi Ogawa-Kishida1,2
1Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, McGovern School of Medicine, Fannin St, Houston, Texas 77030.
bioRxiv : the preprint server for biology
|August 23, 2023
概括
工程细菌和小细胞提供CRISPR/Cas9等离子体以向细菌,增强杀死耐药菌株. 这种编程传递系统 (PDS) 提供了一种针对细菌感染的新策略.
科学领域:
- 微生物学和分子生物学
- 合成生物学 合成生物学
- 抗微生物战略 抗微生物策略
背景情况:
- 抗生素耐药性的增加需要新的抗菌方法.
- 细菌IV型分泌系统 (T4SSs) 对于DNA输送具有多功能性,但缺乏特异性.
- 克里斯普尔/卡斯9系统提供针对细菌抑制的基因编辑.
结论:
- 设计为编程传递系统 (PDS) 的细菌和小细胞显示出有针对性的细菌抑制的潜力.
- PDS为抗击细菌感染提供了一个有希望的替代品或传统抗生素的补充剂.
- 这种平台可以准确地将抗菌有效载荷传递给特定的细菌群体.
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