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Updated: Jul 18, 2025

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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针对PSD-95 PDZ3域的新循环化合物的基于结构的开发

Mandar T Naik1,2, Nandita Naik1,2, Tony Hu2

  • 1Department of Molecular Biology, Cell Biology and Biochemistry.

bioRxiv : the preprint server for biology
|August 23, 2023
PubMed
概括

针对TrkB/PSD-95通路的新型皮相仿药显示,增强结合 afinity 治疗神经系统疾病,如抑郁症和安吉尔曼综合征.

关键词:
安吉尔曼综合征是什么意思抑郁症 抑郁症 抑郁症这就是NMR的NMR.在PSD-95中,我们可以看到PSD-95.基于结构的药物设计.

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Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
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