在老年和年轻人中,冷和热刺激期间脑血量的比较
Shingo Takahashi1, Daishi Takahashi1, Takuro Tamura1
1Department of Healthcare Informatics, Faculty of Health and Welfare, Takasaki University of Health and Welfare, Takasaki, Japan.
Journal of biomedical physics & engineering
|August 23, 2023
概括
与年轻人相比,老年人在温度刺激期间表现出受损的热感和脑血量不明确的变化. 这表明老龄化人口中潜在的感官处理差异.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 感官生理学 感官生理学
背景情况:
- 痴呆与体感皮质的神经元损失有关,影响疼痛和温度感觉.
- 以前关于痴呆症和大脑血液体积的研究通常集中在认知功能和额叶上.
- 使用神经影像对痴呆症患者的热感的研究是有限的.
研究的目的:
- 研究冷和热刺激对老年人和年轻人脑血量的影响.
- 为了比较年龄组之间对热刺激的反应中大脑激活模式.
- 探索热感和老化中的大脑血动力学之间的关系.
主要方法:
- 一项使用近红外光测量额叶皮层中氧化血红蛋白度的观察性研究.
- 在年轻和老年参与者之间的冷和热刺激期间血液氧化和重心值变化的比较.
- 评估两个年龄组的热感受值.
主要成果:
- 年轻的受试者在热刺激期间显示氧化血红蛋白的非显著增加;老年受试者显示没有变化.
- 与老年人相比,年轻人中的重心值较低,与反应值相关.
- 在这两组中,在冷刺激期间没有观察到大脑血液体积的显著变化.
结论:
- 与年轻人相比,老年人表现出受损的热感受值.
- 对于老年人来说,前额叶皮质中对热刺激的反应中大脑血液体积的变化仍然不清楚.
- 需要进一步的研究来阐明底层神经血管机制的热感下降衰老.
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