在接受冠状动脉旁路移植手术的患者口腔微生物群
Thangam Menon1, Supraja Kalyanaraman2
1Department of Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, PH Road, Velappanchavadi, Chennai, 600077 Tamil Nadu India.
Indian journal of thoracic and cardiovascular surgery
|August 23, 2023
概括
患有冠状动脉疾病 (CAD) 的患者通常在口腔微生物群中含有引起牙周炎的细菌. 这项研究在接受冠状动脉旁路移植手术的患者中发现了高水平的特定口腔病原体.
科学领域:
- 微生物学 微生物学
- 心脏病学 心脏病学
- 口腔健康 口腔健康
背景情况:
- 口腔是宿主健康至关重要的复杂微生物群落的所在地.
- 许多研究表明,牙周感染与冠状动脉疾病 (CAD) 之间存在联系.
研究的目的:
- 在被诊断为CAD的患者中调查引起牙周炎的细菌的存在和丰富性.
- 在接受冠状动脉旁路移植 (CABG) 手术的个体中分析口腔微生物组合.
主要方法:
- 用16S核糖体RNA (rRNA) 基因片的元基因组测序来分析口腔微生物组.
- 从重症监护室的5名患者中,分隔48-72小时收集了口服口水样本.
- 评估了细菌菌群的丰富性和多样性.
主要成果:
- 发现的最常见的细菌系是Firmicutes和Bacteroidetes.
- 在这组患者中,蛋白质细菌占口服类型的不到5%.
- 在大多数患者中检测到高数量的关键牙周病原体,包括Tannerella forsythia,Campylobacter rectus,Fusobacterium nucleatum,Prevotella intermedia和Treponema denticola.
结论:
- 接受CABG手术的CAD患者的口腔微生物群的特点是存在大量特定的牙周病原体.
- 虽然出现了短期的术后变异,但整体口腔细菌多样性在很大程度上保持稳定.
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