腹部状质神经元通过分离的投射来调节清醒和情绪
Yan-Jia Luo1,2, Jing Ge1, Ze-Ka Chen1
1Department of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Fudan University, Shanghai 200032, China.
iScience
|August 23, 2023
概括
葡萄糖性腹神经元 (VP) 调节清醒和抑郁行为. 激活这些神经元会增加兴奋和焦虑,而抑制它们会减少这些效应,提供潜在的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 行为科学 行为科学
背景情况:
- 失眠和抑郁症经常同时发生,但涉及的特定神经回路仍然不清楚.
- 以前的研究确定了GABAergic腹神经元在清醒和动机中的作用.
- 其他VP神经元亚型在兴奋和情绪调节中的功能在很大程度上尚未被探索.
研究的目的:
- 调查谷氨酸性VP (VP Vglut2) 神经元在调节清醒和类似抑郁的行为中的作用.
- 阐明VPVglut2神经元控制兴奋和情绪的电路机制.
主要方法:
- 利用成像来监测VPVglut2神经元活动在睡眠-清醒过渡和小鼠的行为测试.
- 采用光遗传技术来激活或抑制VP神经元并评估它们对行为的影响.
- 进行了电路剖析,以追踪VP神经元向下游大脑区域的投射.
主要成果:
- 在NREM睡眠到觉醒过渡期间和在抑郁/焦虑状态中,VP神经元活动增加.
- 激活VP Vglut2神经元促进了清醒,并诱导了焦虑/抑郁类行为.
- 抑制VP神经元减弱了清醒和抑郁/焦虑类行为.
- 发现VPVglut2神经元的特定投射到侧向下丘脑和侧向大脑可以分别调节兴奋和类似抑郁的行为.
结论:
- 谷氨基VP神经元在控制清醒和情绪状态方面发挥着关键作用,包括抑郁和焦虑.
- 来自VPVglut2神经元的明确投射介于兴奋和情绪调节.
- 这些发现为失眠和抑郁症的神经回路提供了新的见解,表明VP神经元是潜在的治疗目标.
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