Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

4.8K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
Metastasis02:30

Metastasis

5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
MicroRNAs01:22

MicroRNAs

21.4K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.4K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

2.5K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Effect of the COVID-19 Pandemic on Treatment Strategies for Secondary Prevention of Hip Fragility Fractures.

The Israel Medical Association journal : IMAJ·2026
Same author

Wounding-induced redirection of sugar transport fuels tissue repair.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Machine-learning prediction of affinity and epistasis in the bovine pancreatic trypsin inhibitor-chymotrypsin complex.

Protein science : a publication of the Protein Society·2026
Same author

Predictors of antidepressant prescribing in schizophrenia: A retrospective analysis.

Schizophrenia research·2026
Same author

Beyond black-box AI: Comparing ChatGPT-4 interpretability and accuracy to CNNs in melanocytic lesions diagnosis.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

Another prospective study on the safety of ondansetron for nausea and vomiting of pregnancy: addressing ongoing concerns.

Frontiers in pharmacology·2026
Same journal

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma.

Molecular oncology·2026
Same journal

From tumor-centric to ecosystem-based hypotheses in brain tumor research and care: Proceedings from The second Brain Tumor Meeting by the Sea organized by Julie Gavard and Eric Chevet, held in St Malo (France), 23-25 March 2026.

Molecular oncology·2026
Same journal

Inhibition of cyclin-dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation.

Molecular oncology·2026
Same journal

In vitro and in silico modelling of ROS1-positive non-small cell lung cancer reveals fusion-dependent tyrosine kinase inhibitor responses.

Molecular oncology·2026
Same journal

The role of miR-335-5p in the redifferentiation of BRAF p.V600E thyroid cancers.

Molecular oncology·2026
Same journal

EXPRESSION OF CONCERN: A Newly Identified 45-kDa JAK2 Variant with an Altered Kinase Domain Structure Represents a Novel Mode of JAK2 Kinase Inhibitor Resistance.

Molecular oncology·2026
查看所有相关文章

相关实验视频

Updated: Jul 18, 2025

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.2K

血清蛋白酶抑制剂减少前列腺癌,乳腺癌和卵巢癌的转移.

Amiram Sananes1, Itay Cohen1, Irit Allon2

  • 1Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Molecular oncology
|August 23, 2023
PubMed
概括
此摘要是机器生成的。

针对美索素和卡利克林6 (KLK6) 蛋白酶的新疗法对晚期前列腺癌,乳腺癌和卵巢癌具有前途. 这些基于粉样β蛋白前体库尼茨蛋白酶抑制剂域 (APPI) 突变的新型药物有效向瘤并抑制转移.

关键词:
癌症成像检查 癌症成像检查卡利克莱因斯 (kallikreins) 是一个转移 转移 转移 转移蛋白酶抑制剂是一种蛋白酶抑制剂.血清蛋白质酶是一种血清蛋白质酶.

更多相关视频

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.6K
Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module
10:39

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module

Published on: June 18, 2015

13.2K

相关实验视频

Last Updated: Jul 18, 2025

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.2K
Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.6K
Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module
10:39

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module

Published on: June 18, 2015

13.2K

科学领域:

  • 在瘤学瘤学.
  • 生物化学 生物化学
  • 药物发现 药物发现 药物发现

背景情况:

  • 目前的癌症疗法主要针对初级瘤,忽视了转移过程.
  • 前列腺癌,乳腺癌和卵巢癌的转移与中素和卡利克林6 (KLK6) 的活性增加有关.
  • 梅索西和KLK6被确定为抗转移干预措施的关键目标.

研究的目的:

  • 开发针对中素和KLK6治疗晚期转移性癌症的新型治疗剂.
  • 评估基于APPI的突变体作为抗转移疗法的疗效和特性.
  • 探索这些药物的癌症成像潜力.

主要方法:

  • 开发人类粉样β蛋白前体昆尼茨蛋白酶抑制剂域 (APPI) 的工程突变.
  • 针对前列腺癌和乳腺癌的APPI-3M,以及针对卵巢癌的APPI-4M的指定.
  • 在 ортотоп模型中进行临床前测试,以评估瘤积累,治疗疗效和药物动力学特性.

主要成果:

  • APPI-3M和APPI-4M突变体在瘤中显示出显著的积累.
  • 在先进转移性癌症的临床前模型中证明了治疗疗效.
  • 在体内表现出很长的保留时间,高亲和力和有利的药理动力学.

结论:

  • 工程APPI突变体代表了转移性前列腺癌,乳腺癌和卵巢癌的有希望的新疗法.
  • 这些药物具有适用于治疗干预和诊断成像的特征.
  • 开发的疗法具有良好的安全性,并且可以在规模上制造.