在严重的三腹吐中压力血液体积:对过导管治疗的影响
Karl-Philipp Rommel1, Christian Besler2, Matthias Unterhuber2
1Department of Cardiology, Heart Center at University of Leipzig and Leipzig Heart Institute, Leipzig, Germany; Cardiovacular Research Foundation, New York, New York, USA.
JACC. Cardiovascular interventions
|August 23, 2023
概括
压力血液体积 (SBV) 预测了经过过导管端到端修复 (TEER) 的严重三管吐 (TR) 患者的结果. 较高的SBV与TEER后更糟糕的结果和较少的症状改善有关.
科学领域:
- 心脏病学 心脏病学
- 心血管生理学心血管生理学
- 干预心脏病学 干预心脏病学
背景情况:
- 经过过导管边缘到边缘修复 (TEER) 的三回 (TR) 患者面临残留风险.
- 压力血液体积 (SBV) 是心力衰竭血液动力学的关键因素,也是潜在的治疗点.
研究的目的:
- 调查SBV在严重TR患者中的作用.
- 评估SBV对三体TEER结果的影响.
主要方法:
- 在TEER之前,对279名严重TR患者进行了右心导管.
- 使用血液动力学变量和心血管模型估计SBV.
主要成果:
- 估计的SBV (eSBV) 与肥胖,/肝功能障碍,心脏重塑和填充压力相关.
- 较高的eSBV与TEER后静脉拥堵减少程度较小有关.
- 升高的eSBV独立预测死亡和心力衰竭住院.
结论:
- eSBV与并发症,晚期心力衰竭和严重TR患者对TEER的反应不佳有关.
- 在这个患者群体中,eSBV预测了不良的临床结果.
- 将SBV估计纳入试验可以识别需要额外治疗的患者.
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