适用于黑色素瘤的特兰胺酸的处方做法:来自色素障碍学会的德尔菲共识
Rashmi Sarkar1, Vignesh Narayan R2, Keshavamurthy Vinay2
1Department of Dermatology, Lady Hardinge Medical College and Hospitals, New Delhi, India.
Indian journal of dermatology, venereology and leprology
|August 23, 2023
概括
这项研究澄清了印度对瘤的特兰胺酸的使用情况,并建议在服用前对血栓塞栓风险进行查和基线凝血测试. 它建立了最佳的剂量和监测,以有效治疗梅拉斯马.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 关于印度用于治疗疹的特兰克萨姆酸 (TXA) 的使用存在模两可.
- 缺乏标准化的指导方针,用于TXA的管理,剂量和监测在瘤治疗.
研究的目的:
- 了解印度皮肤病学家当前对梅拉斯马的特兰胺酸处方模式.
- 制定实用指导方针,用于安全和有效地使用tranexamic酸在瘤管理.
主要方法:
- 一个基于谷歌表格的25个问题调查,由印度色素障碍学会 (Pigmentary Disorders Society, India) 的专家提供意见.
- 该调查分发给全国各地的执业皮肤科医生,随后进行了专家意见改进的轮次调查.
- 共识被定义为至少80%的受访者同意的共识.
主要成果:
- 皮肤病学家一致认为,在开始口服松酸治疗之前,需要对血栓栓塞,心血管和月经障碍进行查.
- 建议对所有患者进行基线凝血概况,并对高风险个体进行进一步测试.
- 首选剂量是每天两次口服250毫克,单独使用或与其他局部治疗一起使用. 对于复发的黑色素瘤,可能需要重复治疗.
- 凝血概况应每三个月监测一次,特别是在高风险患者中. 在改善后,突然停止是可以接受的.
结论:
- 口服特兰胺酸是一种有价值的治疗美拉斯马.
- 持续的结果可能需要间歇性治疗,需要对高凝血状态保持警.
- 标准化的指导方针对于最佳的三胺酸治疗在血中至关重要.
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