对印度标准贴片测试系列的接触过敏与患有亚托皮肤炎的儿童的疾病严重程度相关
Sanjeev Handa1, Rajsmita Bhattacharjee1, Vishal Thakur1
1Department of Dermatology, Venereology & Leprology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Indian journal of dermatology, venereology and leprology
|August 23, 2023
概括
对过敏性接触性皮肤炎 (ACD) 呈阳性测试的亚托皮炎 (AD) 儿童的疾病严重程度更大. 这凸显了补丁测试在评估AD严重性的重要性.
科学领域:
- 皮肤病学 皮肤病学
- 过敏学 过敏学
- 儿科 儿科 儿科
背景情况:
- 新出现的证据表明,阿托皮性皮肤炎 (AD) 和过敏性接触性皮肤炎 (ACD) 之间存在联系.
- 现有的数据有限,对这种关系提出了相互矛盾的观点.
- 接触过敏可能在AD的发病或恶化中发挥作用.
研究的目的:
- 调查被诊断患有亚托邦性皮肤炎的儿童接触过敏的患病率.
- 为了将接触过敏的存在与阿托皮性皮肤炎的临床严重程度相关联.
- 在这个儿科群体中,识别出常见的过敏原,这些过敏原是导致贴片测试反应阳性的原因.
主要方法:
- 进行了一项单一中心的横截面研究,涉及6个月至12岁的被诊断为亚托皮性皮炎的儿童.
- 参与者使用印度标准系列进行了补丁测试.
- 结果措施包括阳性贴片测试的比例,特定过敏原反应性和与阳性相关的因素,与SCORing亚托皮炎 (SCORAD) 指数相关.
主要成果:
- 在136名患有亚托邦性皮炎的儿童中,28名 (20.6%) 呈现出阳性贴片测试反应.
- 发现的最常见的过敏原是香料混合物,二氧化,化六水合物和.
- 与负测试患者相比,阳性补丁测试患者的SCORAD分数显著更高 (P = 0.009).
结论:
- 阳性贴片试验结果,表明接触过敏,与儿科亚托皮性皮肤炎的临床严重程度增加有关.
- 这些发现强调了AD儿童过敏接触性皮肤炎的临床相关性.
- 需要进一步的研究来确定过敏原的相关性,并评估避免策略的影响.
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