收缩与分片反应模式在直肠癌中的相关性
Sonay Kus Ozturk1, Cristina Graham Martinez1, Kieran Sheahan2
1Department of Pathology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Histopathology
|August 23, 2023
概括
在直肠癌中,化疗放射治疗 (CRT) 后的碎片化反应模式更为常见,并且与晚期疾病有关. 收缩模式虽然不那么频繁,但比目前的分级系统提供了更好的预后洞察力.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
背景情况:
- 新辅助化学放射治疗 (CRT) 是直肠癌的标准治疗方法.
- 瘤对CRT的反应可以表现为收缩或碎片化.
- 了解这些模式对于预测结果至关重要.
研究的目的:
- 调查收缩与碎片化模式在直肠癌对CRT反应中的相关性.
- 为了将这些模式与瘤反应的其他指标相关联.
- 评估它们对患者生存的预后价值.
主要方法:
- 分析了两组直肠腺癌患者的队列,这些患者在CRT后有部分反应.
- 瘤反应模式 (碎片化与收缩) 由独立观察员得分.
- 瘤回归分级 (TRG) 用CAP和Dworak分类来评估.
- 使用生存分析和多变量回归来评估预后值.
主要成果:
- 碎片化是占主导地位的响应模式 (70-74%),观察者之间有很好的一致性.
- 分碎的模式与更高的病理阶段 (ypTNM II-IV) 和较少的瘤回归 (Dworak,CAP TRG) 有关.
- 收缩模式在预测整体和无病生存期 (DFS) 中表现优于TRG.
结论:
- 在直肠癌中,瘤对CRT的反应是异质的,碎片化占主导地位.
- 碎片化的模式与晚期和较差的回归相关.
- 虽然不是一个独立的预测因素,但收缩模式提供了有价值的预后信息.
更多相关视频
08:26Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
Published on: March 24, 2023
532
08:08Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence
Published on: June 10, 2025
74
相关概念视频
Assessment of the Rectum and Anus
276
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
276
Shrinkage in Concrete
129
Shrinkage in concrete is primarily due to water loss from evaporation, hydration of cement, or carbonation, leading to a reduction in volume. The volumetric contraction results in volumetric strain in concrete. However, in practice, shrinkage is measured as linear strain, which is one-third of the volumetric strain.
When concrete is still in its plastic state, it can undergo a decrease in volume by about 1% of its absolute volume. This decrease is known as plastic shrinkage. It arises either...
When concrete is still in its plastic state, it can undergo a decrease in volume by about 1% of its absolute volume. This decrease is known as plastic shrinkage. It arises either...
129
