通过协同活动,性一氧化碳释放聚合物作为抗菌和抗生物膜剂
Liping Wang1, Wenbin Zhong1, Bo Liu1
1Centre for Antimicrobial Bioengineering, School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore.
ACS applied materials & interfaces
|August 23, 2023
概括
新的带有一氧化碳释放分子 (CORM) 的阴阳性聚合物显示出增强的抗微生物和抗菌膜活性. 这些聚合物CO载体提供更好的溶解性,降低毒性和长时间的CO释放,有效抑制细菌和真菌.
科学领域:
- 有机金属化学 有机金属化学
- 聚合物科学 聚合物科学
- 抗菌剂 抗菌剂 抗菌剂
背景情况:
- 一氧化碳释放分子 (CORM) 是具有抗菌性能的有机金属化合物.
- 传统的低分子量CORM在溶解性,细胞毒性和释放时间方面存在局限性.
研究的目的:
- 开发用于增强抗微生物应用的新型离子CO释放聚合物.
- 评估这些聚合物对浮游生物和生物膜微生物的疗效.
主要方法:
- [Ru(CO) 3Cl2]2和Mn(CO) 5Br的CORM在聚胺 (PIM) 载体上的结合,形成Ru@PIM和Mn@PIM.
- 评估水溶性,细胞毒性,二氧化碳释放动力学和抗菌活性 (MIC).
- 对*Pseudomonas aeruginosa*的抗菌膜疗效的评估,包括预防和分散已建立的生物膜.
主要成果:
- 与低分子量CORM相比,聚合物CO载体 (Ru@PIM,Mn@PIM) 的水溶性提高,细胞毒性降低.
- 延长CO释放时间和增强抗微生物活性,对抗格拉姆阳性和格拉姆阴性细菌和真菌 (MIC ≤8μg/ml).
- 显著抑制P. aeruginosa生物膜的形成 (>92%降低在16μg/mL) 和强大的分散已建立的生物膜 (log10降低2.5-3.2在≥64μg/mL).
结论:
- 新型阴离子CO释放聚合物显示出优越的抗微生物和抗菌膜特性.
- 这些聚合物为开发具有长效的先进抗微生物剂提供了一个有前途的平台.
- 性质可能有助于CO释放后持续的抗微生物活性,突出了生物医学应用的潜力.
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