[在使用SGLT-2抑制剂时由Candida引起的尿路感染]
Anna M Zeelenberg1,2, Gerard J van der Wielen1, Edith D Beishuizen3
1Haaglanden Medisch Centrum, afd. Urologie, Den Haag.
Nederlands tijdschrift voor geneeskunde
|August 23, 2023
概括
糖转运体2 (SGLT-2) 抑制剂可以导致葡萄糖尿,增加尿路感染的风险. 一个案例研究表明,患者的Candida glabrata感染在停止SGLT-2抑制剂治疗后得到缓解.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
背景情况:
- 糖转运体2 (SGLT-2) 抑制剂是一种新型的抗糖尿病药物.
- 这些药物通过抑制脏葡萄糖再吸收而起作用,导致葡萄糖尿.
- 由于其已证明的脏和心血管益处,SGLT-2 抑制剂越来越多地被处方.
研究的目的:
- 报告与使用SGLT-2抑制剂相关的尿路感染病例.
- 突出SGLT-2抑制剂,葡萄糖尿和真菌性尿路感染之间的潜在联系.
主要方法:
- 病例报告详细介绍了一名在接受SGLT-2抑制剂治疗期间患有尿路感染的患者.
- 在停止使用SGLT-2抑制剂后,对感染消失的临床观察.
主要成果:
- 一名使用SGLT-2抑制剂的男性患者患上了由Candida glabrata引起的尿路感染.
- 在患者停止服用SGLT-2抑制剂药物后,真菌性尿路感染消失了.
结论:
- 葡萄糖是已知的真菌感染风险因素,由SGLT-2抑制剂诱导.
- 虽然真菌性尿路感染在健康人群中不常见,但这种情况表明与SGLT-2抑制剂的潜在关联.
- 需要进行进一步的研究,以确定在接受SGLT-2抑制剂治疗的患者中真菌性尿路感染的最终风险.
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