在接受抗结核治疗的患者中出现眼睛毒性
Sanjeeta Sitaula1, Ranju Kharel Sitaula, Shilu Thapa
1B.P. Koirala Lions Center for Ophthalmic Studies, Institute of Medicine, Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal.
概括
抗结核药物 (如乙胺醇) 的眼睛毒性很少见,但很严重,可能导致视力丧失. 早期症状包括对比度敏感度下降和视网膜神经纤维层变薄,表明亚临床毒性.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 结核病 (TB) 是尼泊尔的一个重大公共卫生问题.
- 抗结核药物可能会导致眼睛的毒性.
- 这项研究调查了正在接受治疗的结核病患者的眼睛毒性.
研究的目的:
- 为了确定在接受抗结核治疗的患者眼部毒性的发生率.
- 在治疗前后评估视觉功能的变化和眼部成像.
主要方法:
- 45名结核病患者 (89只眼睛) 的前性研究.
- 通过OCT评估视觉敏度,色彩视觉,对比度灵敏度,视野和视网膜神经纤维层 (RNFL) 厚度.
- 用于疑似病例的视觉唤起潜力 (VEP).
主要成果:
- 眼部毒性发生率为2.24%.
- 一名患者在乙醇治疗后出现了双边逆巴光学神经病变.
- 在其他患者的RNFL厚度下降表明亚临床毒性.
结论:
- 乙墨醇毒性,虽然不常见,但可以表现为 retrobulbar视神经炎.
- 对比度降低和RNFL稀释是亚临床眼部毒性的指标.
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