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微生理系统在癌症中建模血小板病理生理学的前景
Lopamudra D Ghosh1, Abhishek Jain1,2,3
1Department of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX, USA.
Platelets
|August 23, 2023
概括
血小板通过与瘤细胞相互作用,促进癌症的进展和转移. 通过控制血小板功能,新的生物工程系统为癌症治疗提供了未来的治疗点.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 癌症生物学 癌症生物学
背景情况:
- 血小板在血栓形成和血液静止中至关重要.
- 血小板在促进瘤进展和转移方面也发挥着重要作用.
- 它们在瘤微环境 (TME) 中的相互作用涉及与癌细胞和其他免疫细胞的交叉通话.
研究的目的:
- 审查目前对癌症中血小板生理学的理解.
- 探索TME中血小板与癌细胞的相互作用.
- 检查血小板在化学抵抗和转移中的作用.
主要方法:
- 对现有的体内和体外癌症模型的审查.
- 对血小板癌细胞相互作用的分析.
- 对生物工程微生理系统和器官芯片的批判性评估.
主要成果:
- 血小板与瘤细胞形成聚合物,释放促进癌症生长的因素,并保护瘤细胞免受免疫攻击和剪切力.
- 血小板衍生因素有助于恶性细胞的增殖,转移和化学抵抗.
- 目前从动物模型的临床前理解需要临床翻译.
结论:
- 血小板显著影响癌症的进展,转移和治疗耐药性.
- 生物工程系统代表了研究血小板在癌症中的作用的有希望的未来方向.
- 针对血小板功能为癌症预防和治疗提供了潜在的治疗策略.
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