肌肉骨瘤患者广泛切除后受感染的内膜假体重建的微生物概况:呼吁基于病原体的实践
Rishi Trikha1, Danielle Greig1, Troy Sekimura1
1Department of Orthopaedic Surgery at the University of California, Santa Monica, California, USA.
Journal of surgical oncology
|August 23, 2023
概括
在内膜修复后的周围假肢感染发生在6.2%的病例中. 修复手术和伤口并发症是这些感染的关键风险因素,通常是由葡萄球菌菌种引起的.
科学领域:
- 整形外科手术 整形外科手术
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 周围假肢感染是内侧假肢重建后的一个严重并发症.
- 了解感染发生率,危险因素和微生物特征至关重要.
研究的目的:
- 描述瘤内假体重建后围假体感染的发病率,风险因素和微生物特征.
- 确定与这些感染相关的因素,以改善患者的治疗结果.
主要方法:
- 针对瘤病症的712个内膜假体重建的回顾性审查 (1981-2020年).
- 对人口,瘤,程序和结果数据的分析.
- 多变量逻辑回归用于识别感染风险因素 (p < 0.05).
主要成果:
- 在手术后平均39.9个月内,6.2% (44/712) 的重建中发生了感染.
- 修复手术 (OR 6.14) 和术后伤口并发症 (OR 7.67) 是显著的风险因素.
- 黄金葡萄球菌 (34.1%) 和S. epidermidis (22.7%) 是最常见的;10种感染导致截肢,包括抗微生物耐药和多微生物病例.
结论:
- 观察到大量的围围假体感染,包括多微生物和抗生素耐药类型.
- 这些感染与更糟糕的结果有关,包括截肢.
- 病原体特异性传染性实践可能有必要用于内膜假体重建.
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