将睡眠的振荡事件绘制为阿尔茨海默病的生物标志物
Rachelle L Pulver1,2, Eugene Kronberg1, Lindsey M Medenblik1,2
1Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
概括
睡眠大脑波合的变化,包括 teta 爆发 (TBs) 和慢波 (SWs),可能是早期阿尔茨海默病 (AD) 的信号. 衰老成年人降低合精度与粉样蛋白阳性和认知衰退相关,这表明在家进行EEG监测的可能性.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 睡眠医学 睡眠医学
背景情况:
- 神经回路在睡眠过程中产生诸如泰达爆发 (TBs),睡眠 (SPs) 和慢波 (SWs) 等振荡事件.
- 这些振荡事件在睡眠脑电图 (EEG) 中的改变合可能表明早期阿尔茨海默氏病 (AD) 发病.
研究的目的:
- 为了分析缓慢波-达爆发 (SW-TB) 和缓慢波-睡眠螺旋 (SW-SP) 神经电路合与AD生物标志物和认知状态有关的精度.
- 为了研究睡眠EEG振荡事件合和脑脊液 (CSF) AD生物标志物之间的关联.
主要方法:
- 对205名老年成年人的单通道睡眠EEG数据的分析.
- 测量CSFAD生物标志物 (粉样蛋白-β42/40比,酸化181,总).
- 使用临床痴呆症评分® (CDR®) 尺度评估认知功能.
主要成果:
- 在SW-TB合中,认知障碍与降低的TB光谱功率相关.
- 粉样蛋白阳性个体,即使在认知上没有受损,与粉样蛋白阴性个体相比,也显示SW-TB和SW-SP合精度下降.
- 振荡事件合精度表明与CSF Aβ42 / Aβ40,p-tau181和总tau水平有显著的相关性.
结论:
- 睡眠依赖的内存处理完整性可以通过SW-TB和SW-SP合精度来评估.
- 神经电路合中断与粉样蛋白阳性,AD病理增加和认知障碍有关.
- 家庭睡眠EEG提供了一个潜在的,廉价的生物标志物,用于监测与记忆和早期AD检测相关的神经回路.
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