胎儿下垂体丸抑制对大脑的影响 雄羊的性差异化和生殖功能
Rebecka Amodei1, Sonnet S Jonker2, Mary Smallman3
1Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239-3098, USA.
Endocrinology
|August 23, 2023
概括
在胎儿羔羊中阻断性腺激素释放激素 (GnRH) 并没有改变大脑的性差异化. 然而,它在成年后损害了丸丸激素合成能力,而丸激素替代剂可以逆转效果.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 发育神经科学的发展神经科学.
- 动物繁殖 动物繁殖
背景情况:
- 产前暴露于GnRH抗剂可能会影响胎儿的发育.
- 了解对性差异化的长期影响至关重要.
研究的目的:
- 评估胎儿GnRH抗剂治疗对成年雄羊生殖功能的持久影响.
- 研究对性行为,神经内分泌反应和丸功能的影响.
主要方法:
- 胎儿羔羊接受了用GnRH抗剂脱利克斯 (DG) 的治疗,有/没有 (T) 替代.
- 评估成年雄羊的性二态行为,性伴侣偏好,神经内分泌反应能力和丸功能.
主要成果:
- DG治疗没有影响生殖器分化或体质生长.
- 产前DG抑制了青少年的游戏和成年人的性动机,但没有损害男性的性差异化.
- 用DG治疗的公羊表现出改变的LH和T反应,表明莱迪格细胞功能受损,T替代逆转.
- DG抑制了CYP17的mRNA表达,影响了的生物合成,但没有影响射精质量.
结论:
- 胎儿GnRH对抗性不会永久影响雄羊的大脑的性别分化.
- 中产期的GnRH阻断会损害成年羊的丸丸激素合成能力.
- 替代可以逆转产前GnRH对丸功能的负面影响.
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