严重腹腔大动脉化老年男性的加速骨质丧失-前性MINOS研究
Pawel Szulc1, Joshua R Lewis2,3, Roland Chapurlat1
1INSERM UMR 1033, University of Lyon, Hospices Civils de Lyon, 69437, Lyon, France.
The Journal of clinical endocrinology and metabolism
|August 23, 2023
概括
严重的腹腔大动脉化 (AAC) 与老年男性的骨质损失加快有关. 这一发现表明,在这个人口群体中,骨折风险增加的潜在贡献.
科学领域:
- 老年学是指老年学的学科.
- 心血管健康 心血管健康
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 关于腹腔大动脉化 (AAC) 严重程度和骨损失之间的关系,存在相互矛盾的数据.
- 了解这种关联对于评估老年人群中骨折风险至关重要.
研究的目的:
- 为了研究基线腹腔大动脉化 (AAC) 与老年男性前性测量骨损失之间的关联.
- 量化骨损失的速度与AAC不同程度的关系.
主要方法:
- 展望性队列研究 (MINOS) 涉及778名年龄在50-85岁之间的男性,始于1995年.
- 腹腔大动脉化 (AAC) 通过使用 Kauppila 的得分通过横向脊柱放射测定.
- 骨矿物质密度 (BMD) 和骨矿物质含量 (BMC) 用双能X射线吸收计测量超过7.5年.
- 用于统计分析的线性混合模型.
主要成果:
- 与没有AAC的男性相比,严重的AAC (>6) 与整个部和远端前臂的骨损失显著更快相关.
- 在AAC的最高分位数 (>10) 显示部部,全身和超远半径的骨损失加快.
- 结果对BMD和BMC都是一致的,并且在排除各种混因素的敏感性分析中强大.
结论:
- 严重的腹腔大动脉化 (AAC) 是老年男性加速骨质损失的重要预测因素.
- 这种关联可能部分解释了在严重AAC的男性中观察到的骨折风险增加.
- 对血管化和骨代谢之间的机制进行进一步的研究是有必要的.
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