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在椎间盘中使用MRI指纹来表征与年龄和性别相关的放松参数差异

Rajiv G Menon¹, Anmol Monga¹, Richard Kijowski¹

¹Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, USA.

Journal of magnetic resonance imaging : JMRI

|August 23, 2023

概括

使用MR指纹 (MRF) 的多参数表征可以量化椎间盘 (IVD) 放松参数. 这项研究在IVD放松参数中发现了与年龄相关的显著差异,但没有与性别相关的差异.

科学领域:

放射学放射学是一门学科.
生物医学工程生物医学工程
整形外科整形外科整形外科

背景情况:

多参数定量MRI,特别是MR指纹 (MRF),可以同时测量多个椎间盘 (IVD) 放松参数.
这些定量参数对生物变异敏感,可能因年龄和性别而异.

研究的目的:

用多参数MRF技术研究腰椎IVD放松参数 (T1,T2,T1ρ) 的年龄和性别相关变化.

主要方法:

一项前性研究,涉及17名健康受试者 (8名男性;年龄20-60岁).
在3.0T时使用3D-MRF序列获取质子密度,T1,T2和T1ρ图.
量化了全球和细分IVD放松参数和纹理特征. 斯皮尔曼相关性和曼-惠特尼U测试分析了年龄和性别差异.

主要成果:

在所有腰部IVD中观察到年龄和全球平均T1,T2和T1ρ值之间存在显著的负相关性.
在特定的IVD段中,T1,T2和T1ρ的与年龄相关的下降被注意到.
在全球平均T1,T2或T1ρ值中没有发现基于性别的显著差异.

结论:

3D-MRF技术显示了与年龄相关的IVD放松参数变化在健康个体的特征的潜力.
像T1,T2和T1ρ这样的定量MRI参数是评估IVD衰老的有价值的生物标志物.

关键词:

在MR指纹采集.这是一种退行性退行性.椎间盘之间的椎间盘.肌肉骨系统肌肉骨骨关节炎是一种关节炎.组织特征的表征.

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