长期新生儿单位疫情期间Candida auris殖民的高患病率,南非
Emerging infectious diseases
|August 23, 2023
概括
在南非新生儿病房爆发的Candida auris疫情发现,三分之一的患者被殖民. 快速PCR检测显示出低灵敏度,但在实施隔离和凝聚措施后,感染率下降了85%.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 黄是一种新兴的多抗药性真菌病原体,在全球引起疫情.
- 新生儿单位容易受到Candida auris的殖民和感染,这是由于敏感的患者群体.
- 黄菌疫情需要快速检测和有效的控制策略.
研究的目的:
- 在南非新生儿病房爆发期间评估Candida auris殖民流行率.
- 评估与传统培养方法相比,直接PCR对于快速检测Candida auris殖民的敏感性.
- 确定感染控制干预措施对Candida auris发病率的影响.
主要方法:
- 在Candida auris疫情爆发期间,新生儿病房进行了点患病率调查.
- 直接PCR和真菌培养被用于检测Candida auris殖民.
- 在实施隔离和凝聚方案之前和之后,对感染发病率进行了监测.
主要成果:
- 在接受调查的新生儿患者中,有三分之一的新生儿患有Candida auris.
- 与培养相比,直接PCR在检测殖民时显示出44%的灵敏度.
- 在实施隔离和分组后,Candida auris感染发病率下降了85%.
结论:
- 在疫情爆发期间,新生儿病房中普遍存在Candida auris殖民.
- 在这种情况下,直接PCR对快速殖民检测的敏感性有限.
- 有效的感染控制措施,包括隔离和队列,显著降低了Candida auris感染率.
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