brojler的腺病毒类型D和类型E感染:对CD4和CD8T细胞反应的影响,细胞因子的表达及其免疫病理学
G A Abdel-Alim1, S M Aly2, M S Khattab3
1Department of Poultry Diseases, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt.
British poultry science
|August 23, 2023
概括
禽类腺病毒类型D和E抑制肉免疫力,减少T淋巴细胞并导致淋巴细胞枯竭. 这种免疫抑制可能解释在家禽中观察到的频繁的并发感染.
科学领域:
- 鸟类免疫学 鸟类免疫学
- 病毒学 病毒学
- 禽类病理学 禽类病理学
背景情况:
- 禽类腺病毒 (FAdV) 是家禽中的重要病原体.
- 了解FAdV诱导的免疫抑制对于疾病管理至关重要.
- 以前的研究表明,FAdV会影响免疫系统,但具体的机制需要进一步阐明.
研究的目的:
- 为了研究FAdV-D和FAdV-E血清型在肉中的免疫抑制作用.
- 评估FAdV感染对细胞介导免疫,细胞因子表达和淋巴细胞器官组织病理学的影响.
- 评估FAdV诱导的免疫抑制和复发的现场共感染之间的潜在联系.
主要方法:
- 在实验中用FAdV-D或FAdV-E感染肉.
- 通过通过qPCR量化CD4+和CD8+T淋巴细胞来评估细胞介导免疫力.
- 分析了IL-6和IL-8的mRNA表达,以及在感染后的各种时间点对淋巴体器官 (毛囊,胸腺,) 的组织病理学检查.
主要成果:
- FAdV-D和FAdV-E感染在脏中显著上调炎性细胞因子 (IL-6,IL-8).
- 在FAdV-D和FAdV-E感染组中观察到CD4+和CD8+T淋巴细胞显著减少.
- 组织病理学揭示了淋巴细胞分解,网状细胞增生和感染鸟类淋巴体器官中的淋巴体枯竭.
结论:
- 类型D和E的禽类腺病毒对肉产生显著的免疫抑制作用.
- 观察到的T淋巴细胞减少和淋巴细胞枯竭有助于免疫状况受损.
- 这种免疫抑制是可能导致商业家禽群体报告的病毒共感染发生率增加的一个因素.
更多相关视频
07:26An Ex Vivo Chicken Primary Bursal-cell Culture Model to Study Infectious Bursal Disease Virus Pathogenesis
Published on: October 4, 2018
9.0K
06:57In Vitro Culture for H5N1-Specific Duck T Cells and Detection of Immune Responses Using Intracellular Cytokine Staining Method
Published on: May 30, 2025
159
相关概念视频
01:28Diphtheria
Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
01:20Chickenpox
Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...