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肌缩侧面硬化症的感觉神经病变:一个系统的审查

Alessandro Bombaci^1,2, Antonino Lupica³, Federico Emanuele Pozzi^4,5

¹"Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy.

Journal of neurology

|August 23, 2023

概括

感官神经病变影响到20%的肌缩侧面硬化症 (ALS) 患者,这是致命的神经退行性疾病. 识别这种神经病变可能会改善ALS患者的诊断和生活质量.

科学领域:

神经科学是一个神经科学.
神经学神经学

背景情况:

肌缩侧面硬化症 (ALS) 是一种复杂的神经退行性疾病,影响运动神经元,但最近的证据突显了它的多系统性质.
ALS的症状超越了运动缺陷,包括认知,自主和感官障碍,促使人们对感官神经病变的作用进行调查.

研究的目的:

系统地审查肌缩侧面硬化症 (ALS) 感官神经病变的流行,特征和关联.
确定感觉神经病变是否是ALS谱的重要组成部分及其对患者管理的潜在影响.

主要方法:

系统的文献综述提取了关于ALS感官神经病变的流行病学,临床,神经生理学,神经病理学和遗传特征的数据.
对检测方法 (肌电图,皮肤/神经活检) 的异质性和与临床表现和遗传学相关性的分析.

主要成果:

感觉神经病变在多达20%的ALS患者中存在,影响大和小的神经纤维,具有显著的方法异质性.
感官神经病变可能与脊柱发病和SOD1突变有关,并且似乎与认知障碍相互排斥.
作为神经炎症过程的一部分,ALS和CIDP类神经病变之间的潜在关联需要进一步调查.

结论:

在ALS患者中,应积极查感官神经病变,因为它可能会导致经常报告的感官症状.
将感官神经病变纳入ALS非运动特征的谱中,可以帮助早期诊断和管理.
识别感官神经病变可能会减少诊断延迟,提高患者的治疗和生活质量.

关键词:

肌缩性侧面硬化症 (AMLS) 是一种疾病.神经退行发生神经退行.非运动症状非运动症状感官神经病变是一种神经病变.系统性审查系统性审查

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