中年衰老的迹象:身体功能和微生物群的性别差异
Roy Tzemah-Shahar1, Sondra Turjeman2, Efrat Sharon2
1Faculty of Social Welfare and Health Sciences, University of Haifa, Abba Khoushy Ave 199, 3498838, Haifa, Israel.
GeroScience
|August 23, 2023
概括
肠道微生物群的组成与中年成人身体能力和生物年龄有关. 女性的特定细菌变化与衰老标志物和身体功能相关,这表明有针对性的益生菌干预的潜力.
科学领域:
- 微生物组研究的研究.
- 生物老龄化生物学
- 人类生理学 人类生理学
背景情况:
- 微生物群的组成与身体活动,健康和生物年龄有关.
- 这些因素之间共享的肠道微生物特征仍然未确立.
- 在与年龄相关的疾病出现之前,了解这些中年关系至关重要.
研究的目的:
- 调查肠道微生物群组成和中年人的功能性措施之间的关联.
- 检查与身体能力和生物年龄的关系.
- 为了确定卫生干预的潜在微生物目标.
主要方法:
- 对70名健康中年人 (平均年龄~44.5岁) 的横截面研究.
- 从便样本中使用16S rRNA基因测序进行肠道微生物群的分析.
- 生物年龄通过Klemera-Doubal方法和生物标志物评估;身体能力通过功能测试测量.
主要成果:
- 女性表现出显著更丰富的微生物群多样性.
- 微生物群的多样性与两个性别的时间年龄,生物年龄或身体能力没有相关性.
- 对于女性来说,增加的β多样性与更高的生物年龄和身体能力相关.
- 特定的种类 (例如,Roseburia faecis,Collinella aerofaciens) 与更高的生物年龄/更低的容量相关;其他种类 (例如,Akkermansia muciniphila) 与更年轻的年龄/更高的容量相关.
结论:
- 肠道微生物群的组成可能会调解身体能力和中年健康状况之间的关系.
- 特定的微生物特征与生物年龄和身体功能有关,特别是在女性身上.
- 个性化益生菌可以支持促进健康的干预措施和老龄化率估计.
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