根据SEER数据库和外部队列的数据,为患有后皮质软组织肉瘤的患者提供生存名录
Jing Wu1,2, Yunfei Zhang1, Gang Yao1
1Department of Liver & Laparoscopic Surgery, Center of Digestive and Vascular Surgery, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uyghur Autonomous Region, No.137, Liyushan Rd, Xinshi District, Urumqi, 830054, China.
Journal of cancer research and clinical oncology
|August 23, 2023
概括
新的诺基图准确地预测 retroperitoneal软组织肉瘤 (RPS) 患者的整体生存率 (OS) 和癌症特异性生存率 (CSS). 这些工具有助于更好的风险分层和对这种罕见的癌症的临床决策.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 生物统计学 生物统计学
背景情况:
- 复原皮质软组织肉瘤 (RPS) 是一种罕见的恶性瘤.
- 准确预测整体存活率 (OS) 和癌症特异性存活率 (CSS) 对患者管理至关重要.
- 现有的预后模型可能需要对RPS患者进行改进.
研究的目的:
- 开发和验证用于预测RPS患者的OS和CSS的新型名录.
- 确定影响RPS生存的独立风险因素.
- 评估开发的诺米图的临床实用性和准确性.
主要方法:
- 利用了来自监测,流行病学和最终结果 (SEER) 数据库和单一机构的数据.
- 采用LASSO和COX比例危险回归来确定显著的预后因素.
- 通过使用歧视 (C指数),校准曲线,决策曲线分析 (DCA) 和综合歧视指数 (IDI) 验证的诺莫格拉姆表现.
主要成果:
- 总共分析了1164例RPS病例,分为培训 (n=814) 和验证 (n=350) 队列.
- 诺米图表显示了对OS (C指数=0.728) 和CSS (C指数=0.754) 的良好的区别.
- 校准曲线显示出高预测准确度,IDI显示出优于AJCC分期;风险组之间观察到显著的生存差异 (P<0.001).
结论:
- 新型诺米图提供了对RPS患者的OS和CSS的可靠预测.
- 开发的诺米图表表现出强烈的区分,校准和临床实用性.
- 这些工具可以帮助临床医生对RPS进行风险分层和明智的治疗决策.
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