在初级保健患者的环境温度和功能.
Simeon Schietzel1, Stefan Zechmann2, Fabio Valeri2
1Divison of Nephrology, University Hospital Bern, Bern, Switzerland.
Journal of nephrology
|August 23, 2023
概括
在瑞士的初级保健患者中,高环境温度并没有持续影响功能. 在高度易受伤害的个体中观察到功能小幅下降,但其临床意义仍然不确定.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
背景情况:
- 高环境温度与急性损伤有关,但证据通常来自极端高温事件或紧急环境.
- 社区层面的温度变化对温带气候中功能的影响尚不清楚.
研究的目的:
- 在一个温带气候中的大型初级保健队列中调查环境温度和功能之间的关联.
- 评估易受伤害的患者群体是否会对温度对功能产生差异性影响.
主要方法:
- 这是一项长达9.5年的追溯队列研究,对18,000名瑞士初级保健患者 (FIRE队列) 进行.
- 估计的膜过率 (eGFR) 与五组 (<15°C至≥30°C) 的每日最大环境温度的相关性.
- 对患有慢性心力衰竭,糖尿病,慢性病或服用特定药物 (RAAS抑制剂,利尿剂,NSAIDs) 的患者的相互作用分析.
主要成果:
- 未经调整的分析显示,在所有组中,较高的温度与较低的eGFR有关.
- 调整后的模型显示,环境温度与功能之间没有一致的关联.
- 与<15°C相比,在温度>25°C或>30°C时观察到≥3个风险因素的患者中,观察到边际的逆相关性 (eGFR降低-2.9 ml/min/1.73m2).
结论:
- 在温带气候下的环境温度变化在一般初级保健人口中与功能没有一致的关联.
- 在高度脆弱的患者群体中可能存在轻微的,可能在临床上无关紧要的反向关联.
相关概念视频
01:24Serum Studies: Renal Function Tests
23
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
23
01:28Chronic Kidney Disease III: Interprofessional Care
42
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
42
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
34
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
34
01:17Factors Affecting Renal Clearance: Renal Impairment
119
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
119
01:25Chronic Kidney Disease I: Introduction
35
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
35
01:28Kidney Transplant I: Introduction
29
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
29