使用人口神经科学解决全球环境对心理健康的挑战:一篇综述
Gunter Schumann1,2, Ole A Andreassen3, Tobias Banaschewski4
1Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Clinical Neuroscience, Charité Universitätsmedizin Berlin, Berlin, Germany.
JAMA psychiatry
|August 23, 2023
概括
环境因素在整个生命周期中显著影响大脑健康和精神疾病. 新的研究策略和环境项目旨在揭示开发有针对性的干预措施的大脑机制.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 精神病学是一个精神病学.
背景情况:
- 环境变化 (气候,污染,城市化,不平等,流行病影响) 深刻影响整个生命周期的大脑健康.
- 将环境因素与大脑功能,行为和精神疾病联系在一起的确切机制在很大程度上是未知的.
- 了解这些联系对于解决与环境相关的心理健康状况日益增加的负担至关重要.
研究的目的:
- 概述人口神经科学的研究策略,以确定与环境相关的精神疾病的大脑机制.
- 利用创新的数据整合和丰富工具进行全面分析.
- 为开发针对因果认知和分子途径的新型治疗方法提供信息.
主要方法:
- 使用数据联合策略与创新的丰富工具.
- 整合地理空间观测,气候和污染数据以及数字健康措施.
- 利用EnvironmentMENTAL项目的联合欧洲队列数据 (1.5M+个体) 与深度表型和神经成像数据.
主要成果:
- 环境项目确定了将环境逆境与抑郁,焦虑,压力和物质滥用联系起来的大脑机制.
- 联合数据分析揭示了人口层面对环境对大脑健康影响的洞察力.
- 新的数据整合技术有助于发现复杂的环境与精神疾病关系.
结论:
- 这项研究将产生环境相关精神疾病的客观生物标志物.
- 将开发基于证据的干预措施,针对已确定的大脑机制.
- 预计受环境相关精神疾病影响的个体的结果会有显著的改善.
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