感染Giardia lamblia的学龄前儿童呈现出独立于A,B或E组合的生长延迟
Maria Fantinatti1,2, Tiara Cascais-Figueredo2, Phelipe Austriaco-Teixeira2
1Universidade Federal de Roraima, Curso de Medicina, Boa Vista, RR, Brasil.
Memorias do Instituto Oswaldo Cruz
|August 23, 2023
概括
吉亚迪亚兰布利亚感染会导致学龄前儿童的生长延迟,无论感染组合 (A,B或E) 是什么. 这种寄生虫感染会影响儿童的身体发育,即使在无症状的情况下也是如此.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 众所周知,肠道寄生虫Giardia lamblia (G. lamblia) 损害了儿童的身体发育,特别是导致发育迟缓.
- 兰布利亚菌被分为A-H组合,但它们对临床表现和病变发生的差异性影响尚不清楚.
- 了解组合特异性效应对于儿童群体的向干预至关重要.
研究的目的:
- 调查G. lamblia组合对学龄前儿童身体发育的影响.
- 确定特定的G. lamblia组合是否对幼儿的生长参数产生差异影响.
- 评估G. lamblia感染,组合和巴西社区的身体发育之间的关系.
主要方法:
- 分析了参加日托中心的儿童的人类学参数.
- 收集了便样本,用于G. lamblia的诊断和分离物体的基因定型.
- 进行了统计分析,以将G. lamblia感染和组合与身体发育结果相关联.
主要成果:
- 感染G. lamblia的学龄前儿童,即使在低收入社区中,与未感染的儿童相比,也表现出增长延迟.
- 这种增长延迟效应在三个已识别的组合中一致观察到:A,B和E.
- 这些发现表明,G. lamblia感染对儿童发育有重大影响.
结论:
- 吉亚迪亚兰布利亚感染导致儿童的生长延迟,独立于特定的感染组合 (A,B或E).
- 早期发现和治疗G. lamblia对于预防儿童长期身体发育问题至关重要.
- 对组合特异性毒性因子的进一步研究可以完善理解和治疗策略.
相关概念视频
01:28Fungal Phylum Microsporidia
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
01:18Bacterial Gastroenteritis
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
01:12Giardiasis
Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...