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通过以肠道微生物为中心的治疗来准非酒精性脂肪性肝病
Mijra Koning1,2, Hilde Herrema1,3, Max Nieuwdorp1,2
1Departments of Internal and Experimental Vascular Medicine, Amsterdam University Medical Centers, Location AMC, Amsterdam, The Netherlands.
改变肠道微生物组为非酒精性脂肪性肝病 (NAFLD) 提供了一种新的治疗方法. 本综述涵盖益生菌,便微生物群移植以及针对NAFLD治疗的向疗法.
科学领域:
- 微生物学 微生物学
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
背景情况:
- 人的肠道是微生物复杂的社区.
- 非酒精性脂肪肝 (NAFLD) 与肠道失调和肠道屏障功能受损有关.
- 肠道微生物组在NAFLD的发展中起着至关重要的作用.
研究的目的:
- 探索调节肠道微生物组作为NAFLD治疗策略的潜力.
- 总结目前针对NAFLD的非向和向的基于微生物组的治疗方法.
主要方法:
- 关于肠道微生物组和NAFLD的临床前研究和当前文献的综述.
- 对非向疗法的分析:益生菌和便微生物群移植 (FMT).
- 针对性疗法的评估:工程细菌,前生物,后生物和菌体.
主要成果:
- 肠道微生物组的变化与NAFLD病原发生有关.
- 益生菌和FMT在临床前NAFLD模型中显示出前景.
- 向治疗为NAFLD提供了精确微生物组调节的潜力.
结论:
- 调节肠道微生物组代表了NAFLD的创新治疗途径.
- 对针对微生物的干预措施进行进一步的研究对于NAFLD治疗是有必要的.
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