顺序治疗治疗绝经后骨质疏松症的长期治疗
Sabashini K Ramchand1, Benjamin Z Leder1
1Department of Medicine, Endocrine Unit, Massachusetts General Hospital, Harvard University, Boston, MA 02114, USA.
The Journal of clinical endocrinology and metabolism
|August 23, 2023
概括
顺序性骨质疏松症药物治疗对于长期管理至关重要. 在服用抗吸收药之前开始使用骨形成药物可能会提高治疗效率和骨强度.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 骨生物学 骨生物学 骨生物学
背景情况:
- 骨质疏松症是一种慢性疾病,导致骨质减少和骨折风险增加.
- 目前的骨质疏松症治疗包括抗吸收,骨形成和双重作用药物.
- 长期管理通常需要连续的药物治疗,因为连续单一治疗的局限性.
研究的目的:
- 审查骨质疏松症药物序列的差异性影响.
- 探索有利于骨形成/双重作用药物的证据,其次是抗吸收剂.
- 检查抗吸收剂使用对随后形成骨的药物疗效和停止使用登苏马布的影响.
主要方法:
- 对治疗骨质疏松症的药理学药物的文献综述.
- 测序药物治疗策略的评估.
- 对骨质疏松症管理中的药物有效性和安全性的证据分析.
主要成果:
- 序列治疗在骨质疏松症管理中很常见.
- 有证据表明,使用骨形成药物/双重作用药物开始治疗可能有好处.
- 人们担心,在长期使用抗吸收药物后,骨形成药物的有效性降低.
结论:
- 骨质疏松症药物的最佳顺序对于最大限度地提高骨强度和最大限度地降低骨折风险至关重要.
- 需要进一步的研究,以充分阐明特定的顺序治疗策略的长期益处.
- 预防停止使用登苏马布的临床后果需要仔细考虑后续的治疗方法.
关键词:
类固醇类药物 (Anabolics) 是一种类固醇类药物.抗吸收药是一种抗吸收药.骨矿物质密度 骨矿物质密度骨质疏松症是一种骨质疏松症.骨质疏松症治疗方法 骨质疏松症治疗方法序列治疗疗法 序列治疗更多相关视频
03:56Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention
Published on: April 26, 2024
673
07:12Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
8.2K
相关概念视频
01:40Bone Remodeling
38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
01:29Bone Disorders
3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
01:28Drug Therapy
68
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
68
01:28Menopause
200
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
200
01:26Drug Administration and Therapy Phases: Overview
532
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
532
01:31Osteoclasts in Bone Remodeling
3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K