功能性下丘脑缺血和临床前心血管疾病
Chrisandra L Shufelt1,2,3, Mariam Saadedine1,2, Galen Cook-Wiens4
1Division of General Internal Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
The Journal of clinical endocrinology and metabolism
|August 23, 2023
概括
功能性下丘脑缺血症 (FHA) 的年轻女性表现出内皮功能障碍的迹象,这是临床前心血管疾病标志物. 这种功能障碍与FHA有关,可能不仅仅是由于雌激素水平低.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 心血管疾病研究研究
- 妇女健康 妇女健康
背景情况:
- 内皮功能障碍是心血管疾病 (CVD) 的早期指标.
- 功能性下丘脑缺血 (FHA) 涉及神经内分泌变化,可能会增加年轻女性心血管疾病的风险.
研究的目的:
- 在被诊断患有FHA的妇女中评估内皮功能.
- 为了比较FHA妇女的内皮功能与eumenorrheic对照和最近更年期妇女.
主要方法:
- 一项横截面研究包括30名患有FHA的女性,29名湿疹控制群和30名更年期妇女.
- 使用 EndoPAT 2000 的反应性高血压指数 (RHI) 测量了内皮功能; RHI ≤1.67 表示功能障碍.
- FHA的标准包括3个月以上的异常,低雌激素,FSH和LH,不包括其他原因.
主要成果:
- 与对照组 (2.2 ± 0.5) 和更年期妇女 (2.2 ± 0.6) 相比,患有FHA的妇女的RHI显着较低 (1.8 ± 0.5).
- 35%的女性患有FHA表现出内皮功能障碍 (RHI ≤1.67).
- 与对照组相比,FHA与更低的胰岛素和更高的皮质醇水平有关.
结论:
- 内皮功能障碍存在于约三分之一的年轻女性FHA.
- FHA可能有助于年轻女性临床前心血管疾病的发展.
- 在FHA中观察到的内皮功能障碍不仅仅是由于低雌激素血.
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