在调制器时代的健康不平等
John B Palla1, Theresa A Laguna2
1Division of Pulmonary and Sleep Medicine, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Current opinion in pulmonary medicine
|August 23, 2023
概括
患有囊性纤维化 (CF) 的人面临着严重的健康不平等. 新的CFTR调节器可能会加剧这些差异,因为不平等的获取和高成本,影响全球弱势群体.
科学领域:
- 医学研究 医学研究
- 健康 公平 卫生 公平
- 药理学 药理学是指药理学的学科.
背景情况:
- 囊性纤维化 (CF) 不成比例地影响边缘化人口.
- 在CF中存在的健康差异包括社会经济地位 (SES),种族,种族,性别和性性别少数群体地位.
- 这些差异表现为增加的肺部恶化,较差的营养状况,肺功能减弱和较高的死亡率.
研究的目的:
- 审查目前囊性纤维化 (CF) 患者的健康不平等情况.
- 分析新型囊性纤维化跨膜调节器 (CFTR) 调节器对这些现有的健康差异的潜在影响.
主要方法:
- 对CF健康不平等现有研究的文献综述.
- 对CFTR调节器的可访问性和资格标准的分析.
- 检查CFTR调节器治疗对社会经济和全球成本的影响.
主要成果:
- 来自低SES背景的CF患者体验到更糟糕的健康结果,并减少了获得肺移植的机会.
- 患有CF的种族和民族少数群体面临较早的死亡率,较低的肺功能,延迟诊断,以及在临床试验中的代表性不足.
- 女性性别和性性别少数群体代表了CF中健康结果较差的弱势群体.
- 由于成本高昂,CFTR调节器在很大程度上无法进入低收入和中等收入国家.
结论:
- 在多样化的CF患者群体中,健康不平等仍然存在,包括低SES,种族/民族少数群体,女性和性性别少数群体.
- 由于遗传资格和高昂的成本,对CFTR调节器的不平等获取可能会加剧现有的健康差异.
- 解决这些不平等问题需要采取多方面的方法,重点是平等地获得先进疗法,如CFTR调节器,无论是在个人还是全球范围内.
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