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与农业化学品使用相关的视觉和神经功能受损
Ingrid Astrid Jiménez Barbosa1, Martha Fabiola Rodríguez Alvarez2, Laila Cristina Bernal Bechara3
1School of Optometry and Vision Science, The University of New South Wales, Sydney NSW, Australia.
PloS one
|August 23, 2023
概括
农药工人的职业农化物暴露与神经毒性症状和基本 (颜色,对比度) 和高级 (全局形式,运动) 视觉功能的显著缺陷有关. 这突显了农药暴露对视觉感知的潜在风险.
科学领域:
- 职业健康 职业健康 职业健康 职业健康
- 神经毒理学 神经毒理学
- 视觉神经科学 视觉神经科学
背景情况:
- 农业化学品,包括杀虫剂,在农业中被广泛使用.
- 职业接触农药可能会对神经和感官功能构成风险.
- 以前的研究表明,农药暴露和视觉障碍之间存在潜在的联系.
研究的目的:
- 调查职业农化学物质暴露与视觉功能之间的关联.
- 评估低级 (颜色,对比度敏感性) 和高级 (整体形状,运动感知) 的视觉表现.
- 为了将视力缺陷与神经毒性症状和生物标志物相关联.
主要方法:
- 在暴露于农药的工人和未暴露的人之间比较视觉性能 (色彩区分,对比度灵敏度,全局形状/运动检测).
- 使用修改后的问卷 (Q16) 量化神经毒性症状.
- 测量的生物标志物:血液中的乙胆酶和膜中的P物质.
主要成果:
- 暴露的工人报告了显著更多的神经毒性症状.
- 在乙胆酶水平上没有显著差异,但在两组之间的P物质水平上有显著差异.
- 暴露的工人表现出较差的对比度敏感性,颜色歧视,以及更高的全球形状和运动检测值.
结论:
- 职业农业化学品暴露与视觉感知缺陷有关.
- 这些缺陷影响低级和高级视觉处理.
- 研究结果表明,农药暴露,神经毒性和视觉功能受损之间存在联系.
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