双主动脉:长期发病率和死亡率
Li-Tan Yang1,2, Zi Ye1, Muhammad Wajih Ullah1
1Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
European heart journal
|August 23, 2023
概括
双主动脉 (BAV) 导致了显著的终身发病率,几乎所有患者在90岁时都会发展出状动脉. 虽然典型的BAV具有正常的生存率,但复杂的BAV与死亡率的增加有关.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 双动脉 (BAV) 是最常见的先天性心脏缺陷.
- 在BAV患者亚组中,终身发病率和生存率的变化仍然不清楚.
研究的目的:
- 为了评估BAV患者的终身发病率负担.
- 评估不同BAV患者亚组的长期生存率.
主要方法:
- 对奥尔姆斯特德县居民的回顾性队列研究,在1980-2009年间被诊断患有BAV.
- 患者被分为典型和复杂的膜动脉动脉病组.
- 长期随访以评估发病率和生存结果.
主要成果:
- 90岁时观察到高终身发病率 (86%),其中80.3%进展到中度或重度的大动脉狭窄/吐.
- 典型的BAV患者 (86%的队列) 的生存率与一般人群相比较.
- 复杂BAV患者 (14%的队列) 的死亡率明显较高 (相对过度风险为2.25).
结论:
- BAV导致了相当大的终身发病率,而膜动脉动脉病几乎是普遍存在的.
- 典型的BAV与正常的长期存活率有关.
- 复杂的BAV显著增加死亡风险,突出了风险分层的必要性.
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