遗传多态性对环胺的耐受性和临床疗效的影响在患有狼性炎的埃及患者中
Nermeen N Abuelsoud1, Engy M El Khateeb2
1Department of Pharmacy Practice and Clinical Pharmacy, College of Pharmacy, Egyptian Russian University.
Pharmacogenetics and genomics
|August 23, 2023
概括
该CYP2B6 c.516G>T多态性影响环胺 (CYC) 在埃及狼性炎患者的疗效和毒性. 该T等位基因与改善的CYC有效性和改变的毒性概况有关,这表明它有可能进行个性化治疗.
科学领域:
- 药物基因组学 药物基因组学
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 环胺 (CYC) 是狼性炎 (LN) 的关键免疫抑制剂.
- 遗传变异,如CYP2B6 c.516G>T,可能会影响CYC的临床结果.
- 之前的研究还没有全面评估与这种多态性相关的疗效和毒性.
研究的目的:
- 为了研究CYP2B6c.516G>T多态性 (rs 3745274) 和CYC疗效和耐受性的17个参数之间的关联.
- 评估这种特定基因变异在患有性炎的埃及患者中的作用.
主要方法:
- 一项前性队列研究,涉及142名埃及狼肺炎患者.
- 收集和分析了CYC疗效和毒性的临床数据.
- 患者的基因型为CYP2B6c.516G>T多态 (rs 3745274) 的基因型.
主要成果:
- 在基因型之间观察到13个有效性参数中的11个具有显著差异.
- 在许多临床参数中,T等位基因的存在与增强的CYC疗效有关.
- 在基因型之间注意到肝毒性,腹和血液毒性的统计学显著差异.
结论:
- 这是第一个在埃及LN患者中检查CYC疗效和耐受性与CYP2B6 rs 3745274相关的17个参数的研究.
- 在这种人群中,CYP2B6多态性对治疗反应和毒性起着作用.
- 治疗前对CYP2B6 rs 3745274的基因定型可以帮助预测个人对CYC治疗的反应.
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