神经性厌食症和神经性 Bulimia 神经性 Iatrogenic 触发因素:世卫组织安全数据库不成比例性分析
Diane Merino1, Alexandre Olivier Gérard2, Alexandre Destere3
1Department of Psychiatry, University Hospital of Nice, Nice, France; Department of Pharmacology and Pharmacovigilance Center of Nice, University Hospital Center of Nice, Nice, France.
Psychiatry research
|August 23, 2023
概括
某些药物可能会引发诸如神经性厌食症 (AN) 和神经性吃症 (BN) 等饮食障碍. 异思类胺,抗逆转录病毒药物和其他药物在全球安全数据库分析中被标记为标记.
科学领域:
- 药物监督 药物监督 药物监督
- 精神病学是一个精神病学.
- 皮肤病学 皮肤病学
背景情况:
- 饮食障碍,包括神经性厌食症 (AN) 和神经性嗜食症 (BN),是复杂的疾病,通常与心理和环境因素有关.
- 这些疾病的潜在催化剂 (药物诱导) 触发因素仍然是一个需要进一步研究的领域.
- 现实世界的不良事件数据为识别潜在的与药物相关的安全信号提供了宝贵的资源.
研究的目的:
- 通过使用全球药物监测数据库,调查神经性厌食症 (AN) 和神经性 Bulimia (BN) 的潜在阳性触发因素.
- 为了确定与儿童和成人群体中的AN和BN报告不成比例地相关的特定药物.
- 评估对有助于饮食障碍发展或复发的催产素原因的假设.
主要方法:
- 利用世界卫生组织的VigiBase®安全数据库进行AN和BN报告.
- 根据患者年龄,分类报告为儿科和成人类别.
- 使用信息组件 (IC) 检测安全信号的不成比例性分析,需要 95% 置信区间的正下端.
主要成果:
- 总共分析了309份AN和499份BN报告.
- 异丁氨酸在儿科AN,成人AN和儿科BN中显示出不成比例的报道.
- 抗逆转录病毒药物 (lamivudine,nevirapine,zidovudine) 和精神药物/荷尔蒙活性药物分别与成年人中的AN和BN有关.
结论:
- 诸如异类胺,某些抗药,抗逆转录病毒药物,精神药物和荷尔蒙活性药物等药物可以作为AN和BN的阳性催化剂.
- 医疗保健提供者在评估患有饮食障碍或有饮食障碍风险的患者时,应考虑与滥用一起的阳性原因.
- 对心理健康状况的治疗前评估对于识别有风险的个体和预防AN或BN发展/复发至关重要.
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