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Updated: Jul 18, 2025

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
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基于1,5-二胺的2-替代HDAC抑制剂对人类固体和急性髓性白血病细胞系施加抗癌作用

Simona De Vita1, Sara Meninno2, Lucia Capasso3

  • 1Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.

Bioorganic & medicinal chemistry
|August 23, 2023
PubMed
概括

我们开发了使用1,5-西胺支架的新型基因素脱乙酶抑制剂 (HDACi). 这些化合物显示出强大的纳米分子HDAC抑制,并对癌细胞表现出细胞毒性作用,突出显示了它们作为流行药的潜力.

关键词:
2替代的1,5-西亚胺.它具有抗癌活性.药物设计 药物设计选择性合成 选择性合成在HDAC的基础上,HDAC是分子对接是分子对接.

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