生物年龄作为在同一住院期间计划外重症监护再入院的预测因素
1Department of Intensive Care Medicine, Fiona Stanley Hospital, Medical School, University of Western Australia, and School of Veterinary & Life Sciences, Murdoch University, Perth, WA 6150, Australia.
Heart & lung : the journal of critical care
|August 23, 2023
概括
生物年龄预测了计划外的重症监护室 (ICU) 再入院情况. 具有较高生物年龄加速的患者在同一住院期间更有可能被重新接收到ICU.
科学领域:
- 生物医学科学 生物医学科学
- 老年学是一门学科.
- 关键护理医学 关键护理医学
背景情况:
- 生物年龄是一个关键的健康预测因素,但其在急性护理中的作用尚不清楚.
- 在重症监护室 (ICU) 评估生物年龄的实用性对于患者的治疗结果至关重要.
研究的目的:
- 确定ICU入院时的生物年龄是否预测同一住院期间未计划的ICU再入院.
- 调查生物衰老加速与再接收风险之间的关系.
主要方法:
- 莱文的PhenoAge模型,利用DNA甲基化生物标志物,计算了生物年龄.
- 生物年龄加速 (PhenoAgeAccel) 被定义为生物年龄超过时间年龄.
- 对2950名患者的队列进行了再入院率和PhenoAgeAccel的分析.
主要成果:
- 5.2%的患者经历了未计划的ICU再入院.
- 在重新入院的患者中,PhenoAgeAccel的患病率明显高 (52%对43%,p=0.031).
- 在调整后,增加生物年龄加速显示了与剂量相关的再接收风险增加 (OR1.12,p=0.040) .
结论:
- 生物年龄是计划外的ICU再入院的重要预测因素.
- PhenoAgeAccel可以作为一种有价值的生物标志物,用于识别处于再入院风险较高的患者.
- 进一步的研究可以探索在重症监护机构针对生物年龄的干预措施.
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